Mendocino is about 175 miles north of San Francisco.

From the South: take 101 north to 128 and go west about 60 miles to Highway 1.
Take Highway 1 north to Mendocino.

From the North (Oregon or Washington); take 1-5 south to Grants Pass, then 199 to Crescent City. Take 101 south to Leggett. Turn south on Highway 1 to Mendocino.
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